Peptides are chains of amino acids isolated over decades of research, providing advancements in healing in all realms of medicine. anti-aging and regenerative medicine included. One of the more commonly used peptide is Thymosin Beta 4 (TB4).
TB4 has demonstrated a key role in general cellular function and modulation of the immune system. It is often prescribed for surgical repair and acute injury, especially among athletes.
TB4 has been shown to promote the development of new tissue fibers, blood cell and new blood vessel production.
It has been linked to enhance recovery from trauma and injuries due to its potent role in tissue regeneration, remodeling and repair.
This blog post will review the science and benefits of TB4 and how it might help you optimize your health and healing.
What is Thymosin Beta 4 (TB4)?
Thymosin Beta 4 is a naturally occurring peptide found in all cells in humans and animals except the red blood cells. It is related to Thymosin which is an important immune system hormone secreted from the thymus gland. TB4 has been used extensively in race horses to prevent injury and promote healing. It is low in molecular weight which allows its quick migration to sites in the body that need healing. TB4 is currently in clinical trials for the treatment of HIV, AIDS and influenza.
How does TB4 work?
TB4 enacts it benefits through the following mechanisms. *, **
Increases actin, a protein that builds cells and muscles essential for cell movement and muscle contraction. This promotes cell growth, healing and migration.
TB4 travels to sites of injury to promote healing.
TB4 is found in high concentrations in platelets which are one of the first cells to show up at injury for repair
TB4 decreases cells promoting scar tissue so in return decreases scar formation and fibrosis
TB4 decreases inflammation by preventing the activation of inflammatory cells so repair is faster
Benefits of TB4?
Accelerates wound healing and repairs soft tissue injury
Prevents scar formation and fibrosis
Supports stem cells to heal and regenerate tissue
Regenerates blood cells
Enhances muscle growth
Improves strength and endurance
Reduces acute and chronic pain
Protects the brain, restores neurons after Traumatic Brain Injury
Promotes healing from spinal cord injury
Protects the heart and repairs vessels – especially after a heart attack
Promotes hair growth
Improves the immune system
Promotes healing from eye infection, injury and dry eye disorders
Due to the profound biological activity of TB4, it exerts a diversity of therapeutic effects on various diseases and injuries depicted here:**
TB4 has been reported safe with no significant adverse effects.
Note there is controversial research on TB4 and cancer as increased TB4 levels are found in affected tissues of cancer patients compared to controls. The question at hand is: Is the increase of TB4 in the affected tissues a healing mechanism and immune response or is it involved in carcinogenesis? Since TB4’s main mechanism is to decrease transcription of NFKB cells and therefore decrease inflammation and cellular proliferation, it seems most likely the increase in TB4 cells in cancer patients is a protective mechanism.***
The revolutionary advancement of peptides in medicine is amazing and exciting. More healing benefits are being discovered every day. TB4 has various therapeutic uses, from surgery and soft tissue injury repair, Traumatic Brain Injury, to reversal of neurotoxicity and deleterious effects of heart attack. TB4 is often used in conjunction with BPC 157 and Thymosin Alpha 1 (TA1) to offer even more benefits. Ongoing and future clinical trials of TB4 may reveal even more diversity to its uses and full potential for the future of medicine.